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Purposely Live to120

~ Living to the full potential life-span with full vigor

Tag Archives: Epigenetic Signature

Post #13 – Ever heard of Functional Medicine?

27 Tuesday May 2014

Posted by purposelyliveto120 in Aging, Functional Medicine, Living to 120, Reversing Chronic Diseases, Vigor, Vitality

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Acute Diseases, Allergies, Chronic Disease, Epigenetic Signature, Health Span, Preventative Care, Reversing Chronic Diseases, Vitality

In my previous blog posts, I have talked about curing my allergies, fixing migraines, and curing a whole host of other issues without pharmacological medicines. Yes, actually curing these issues and not just managing or controlling the symptoms.

For the longest amount of time, I found it difficult to talk about to these things with my physicians or even lay people. I must admit it all sounded so much like woo doo even to me as I would talk about it. A common refrain from doctors was, “We only practice evidence based medicine.” I did not know what to believe or not believe, except that from my personal experience (evidence of n=1), I could prove that these things work.

All that changed, when last year Kimberly and I attended the Health and Wellness Conference 2013 at the University of Maryland, School of Medicine at the Center of Integrative Medicine in Baltimore, Maryland. There we heard talks about yoga, Qi Gong, nutrition, meditation, detoxing, and many other so called “alternative” therapies in the setting of Evidence Based Medicine.

Key note speaker was Mark Hyman, MD. He has a private practice Ultra Wellness Center in Massachusetts. He wrote a book, The Blood Sugar Solution, which received endorsement from President Bill Clinton. He talked about the diagnosis and cure of Diabesity, a term he has coined as combination of diabetes and obesity. And, he talked about diabesity in the context of what he called Functional Medicine.

Since then I have studied up quite a bit on Functional Medicine and I do believe that many of my conversations in my blog posts fit in that framework. More I dig into this topic the more entranced I am getting with this topic. I feel that functional medicine is the key to the kingdom, when it comes to wellness, vitality and living the optimal health span and life span.

Jeffrey Bland, Ph.D. is considered “father” of this field. Mark Hyman calls him his mentor. Among Bland’s other accomplishments, he has founded Personalized Lifestyle Medicine Institute and The Institute for Functional Medicine. Recently, he has written a book, “The Disease Delusion, Conquering the Causes of Chronic Illness for a Healthier, Longer, and Happier Life.”

Institute for functional medicine describes functional medicine as follows:

“Functional medicine addresses the underlying causes of disease, using a systems-oriented approach and engaging both patient and practitioner in a therapeutic partnership. It is an evolution in the practice of medicine that better addresses the healthcare needs of the 21st century. By shifting the traditional disease-centered focus of medical practice to a more patient-centered approach, functional medicine addresses the whole person, not just an isolated set of symptoms. Functional medicine practitioners spend time with their patients, listening to their histories and looking at the interactions among genetic, environmental, and lifestyle factors that can influence long-term health and complex, chronic disease. In this way, functional medicine supports the unique expression of health and vitality for each individual.”

So, the basic idea of functional medicine is to take a systems approach to disease and wellness rather than either chasing symptoms or taking germ theory approach that generally focuses on single point of correction. In his book, Jeffrey Bland talks of seven different systems for our bodies:

  1. Assimilation and Elimination
  2. Detoxification
  3. Defense
  4. Cellular Communication
  5. Cellular Transport
  6. Energy
  7. Structure

So the objective in functional medicine is to investigate symptoms to pinpoint one or more of these seven systems that are not working properly and then to change diet, exercise and lifestyle to fix the system imbalance and thereby the diseases and the symptoms.

The end result is often pretty low tech, and may seem underwhelming. That is, implement changes in diet, exercise and lifestyle to redirect expression of certain genes to cure a disease.

However, approach to getting there can be fairly high-tech in identifying the true root cause, identifying the systems that are out of balance and gene expressions that may be responsible for the underlying imbalance. And, as you see from the stories, results can be very profound and almost magical.

If you know someone, who is being treated for certain symptoms of chronic diseases by meds. e.g., high blood pressure, obesity, brain fog, constant fatigue, high cholesterol, inflammation, muscle aches, etc..  The meds being used often lead to side effects that need to be treated by other meds, which in turn are causing other side effects etc.. Such a person is the perfect candidates for functional medicine.

Have you heard of functional medicine?

Do you have any experience with functional medicine?

I have been looking for good certified functional medicine practitioners in our area that we could consult and also recommend to our friends and family. We have access to some lists, but no personal experience yet. Do you know of such a practitioner?

I would love to learn if you know someone.

Post #7 – Can biomarkers help in the quest for vitality and longevity?

14 Monday Apr 2014

Posted by purposelyliveto120 in Aging, Life-Span, Living to 120, Vigor, Vitality

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Aging, Biomarkers, Epigenetic Signature, Life Span, Lifespan, living to 120, optimal health, Telomere, Vitality

How do we die and how do we lose vitality questions so far have focused my attention on the hurdles to overcome. Some of these have to do with challenges that shorten or bring end to our lifespan. Other items are “diseases” that can decrease our vitality and vigor.

All of these items are, of course, important. For the moment, however, let me step away from these hurdles and reframe the questions.

Let us say, I don’t really have any disease, but I want to live a lifestyle to achieve the optimal health and lifespan. How can I objectively assess where I am presently and then either maintain or improve from here? In other words, how to pursue living an optimal health and vitality, not merely trying to be disease free?

Study of Biomarkers has been an area of aggressive research and pursuit in vitality and aging since the 1980’s.

Biomarkers (short for biological markers) are biological measures of a biological state. By definition, a biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes or pharmacological responses to a therapeutic intervention.

In the context of aging, an important focus for biomarkers has been on finding “the clock” that potentially ticks away our lifespan. Discovery of telomere as a potentially genetic clock is one example of a biomarker that won Elizabeth Blackburn of the University of California San Francisco a Nobel Prize. More recently, Steve Horvath of UCLA has introduced another important biomarker to measure human aging through epigenetic signatures.

Both of these works have sparked fascinating research into areas of aging and extending lifespans. I would like to explore these topics in future blog posts.

On the other hand, for vitality, William Evans, PhD, and Irwin H. Rosenberg, MD, professors of nutrition and medicine, respectively, at Tufts University introduced a concept of biomarkers back in 1991 through their book Biomarkers (Simon and Schuster, 1991), updated in their book, BIOMARKERS: The 10 Keys to Prolonged Vitality (Simon and Schuster, 1992) and more recently updated in the Tufts University Health and Nutrition Letter.

In these publications, Evans and Rosenberg isolated the following signposts of vitality that can be altered for the better by changes in lifestyle:

  1. Muscle Mass
  2. Strength
  3. Basal Metabolic Rate
  4. Body Fat Percentage
  5. Aerobic Capacity
  6. Blood-sugar Tolerance
  7. Cholesterol/HDL Ratio
  8. Blood Pressure
  9. Bone density
  10. Ability to regulate Internal Temperature

These same 10 biomarkers keep showing up everywhere in preventative care, in strength training, in other training programs, in nutrition/diet plans and so on.

Additionally, other important biomarkers I have seen show up in various medical and scientific literature and studies on health, vitality and longevity are:

  1. Stress
  2. Inflammation
  3. Sleep
  4. Body’s pH
  5. Flexibility
  6. Balance
  7. Musculoskeletal alignment
  8. Physical and mental reaction time

So, the way I see it is this: the goal of achieving optimal health and lifespan should focus on developing lifestyle that optimizes these objectively measureable / observable biomarkers.

Any exercise plan, nutrition plan, lifestyle adaptations, and any medical program for achieving optimal vitality and lifespan thus must be measured against these criteria.

What do you think?

Do you know of other biomarkers that we can impact that are important for attaining optimal vitality and lifespan?

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  • Post #66 – Optimal Health through Optimal Breathing
  • Post #65 – Fasting, the old new technology and panacea for Optimal Health – Part III
  • Post #64 – Fasting, the old new technology and panacea for Optimal Health – Part II
  • Post #63 – Fasting, the old new technology and panacea for Optimal Health – Part I
  • Post #61 – How much sleep do we need for optimal health?

Recent Comments

purposelyliveto120 on Post #66 – Optimal Health thro…
Michael Jansen Jr. on Post #66 – Optimal Health thro…
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